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Wavelengths and temporal effects on the response of mammalian cells to UV radiation: Limitations of action spectra illustrated by genotoxicity
- Source :
- Journal of Photochemistry and Photobiology B: Biology, Journal of Photochemistry and Photobiology B: Biology, 2021, pp.112169. ⟨10.1016/j.jphotobiol.2021.112169⟩, Journal of Photochemistry and Photobiology B: Biology, Elsevier, 2021, pp.112169. ⟨10.1016/j.jphotobiol.2021.112169⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- All photobiological events depend on the wavelength of the incident radiation. In real-life situations and in the vast majority of laboratory experiments, exposure always involves sources with various emission spectra spreading over a wide wavelength range. Action spectra are often used to describe the efficiency of a process at different wavelengths and to predict the effects of a given light source by summation of the individual effects at each wavelength. However, a full understanding of the biological effects of complex sources requires more than considering these concomitant events at each specific wavelength. Indeed, photons of different energies may not have additive but synergistic or inhibitory effects on photochemical processes and cellular responses. The evolution of a photobiological response with post-irradiation time must also be considered. These two aspects may represent some limitations to the use of action spectra. The present review, focused on mammalian cells, illustrates the concept of action spectrum and discusses its drawbacks using theoretical considerations and examples taken from the literature. Emphasis is placed on genotoxicity for which wavelength effects have been extensively studied. Other effects of UV exposure are also mentioned.
- Subjects :
- Keratinocytes
Photon
DNA Repair
Ultraviolet Rays
Biophysics
Radiation
medicine.disease_cause
Spectral line
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Emission spectrum
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Action spectrum
Physics
0303 health sciences
Radiological and Ultrasound Technology
Oxidative Stress
Wavelength
Action (philosophy)
Pyrimidine Dimers
030220 oncology & carcinogenesis
Mutation
Action Spectrum
Biological system
Genotoxicity
DNA Damage
Subjects
Details
- Language :
- English
- ISSN :
- 10111344
- Database :
- OpenAIRE
- Journal :
- Journal of Photochemistry and Photobiology B: Biology, Journal of Photochemistry and Photobiology B: Biology, 2021, pp.112169. ⟨10.1016/j.jphotobiol.2021.112169⟩, Journal of Photochemistry and Photobiology B: Biology, Elsevier, 2021, pp.112169. ⟨10.1016/j.jphotobiol.2021.112169⟩
- Accession number :
- edsair.doi.dedup.....1bb6ce0e02f50d14b9b660dda1955c85