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Pyrrole: An insight into recent pharmacological advances with structure activity relationship
- Source :
- European Journal of Medicinal Chemistry. 157:527-561
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for the generation of library of enormous lead molecules. Owing to its vast pharmacological profile, pyrrole and its analogues have drawn much attention of the researchers/chemists round the globe to be explored exhaustively for the benefit of mankind. This review focusses on recent advancements; pertaining to pyrrole scaffold, discussing various aspects of structure activity relationship and its bioactivities.
- Subjects :
- Anti-HIV Agents
Antitubercular Agents
Antineoplastic Agents
010402 general chemistry
Ring (chemistry)
01 natural sciences
Antimalarials
Structure-Activity Relationship
chemistry.chemical_compound
Drug Discovery
Animals
Humans
Structure–activity relationship
Pyrroles
Antihypertensive Agents
Pyrrole
Pharmacology
Molecular Structure
010405 organic chemistry
Anti-Inflammatory Agents, Non-Steroidal
Organic Chemistry
General Medicine
Anti-Ulcer Agents
Combinatorial chemistry
Antidepressive Agents
Anti-Bacterial Agents
0104 chemical sciences
chemistry
Pharmacophore
Subjects
Details
- ISSN :
- 02235234
- Volume :
- 157
- Database :
- OpenAIRE
- Journal :
- European Journal of Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....1bae3abe72a8a0a6ee92d5260e639f6d