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Incidence of hand–foot syndrome with capecitabine in combination with chemotherapy as first-line treatment in patients with advanced and/or metastatic gastric cancer suitable for treatment with a fluoropyrimidine-based regimen
- Source :
- Clinical and Translational Oncology. 14:689-697
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Hand-foot syndrome (HFS) is a limiting toxicity of capecitabine, which is not life-threatening but could compromise capecitabine efficacy.This phase II, multicenter, non-controlled study assessed the safety, particularly grade three HFS incidence, and efficacy of four capecitabine-based chemotherapy regimens [cisplatin/capecitabine (CX), epirubicin/cisplatin/capecitabine (ECX), epirubicin/oxaliplatin/capecitabine (EOX) and docetaxel/cisplatin/capecitabine (DCX)] as first-line treatment for advanced and/or metastatic gastric cancer.One hundred and eight patients were assigned to one of the four treatment groups, according to investigator's criteria, and grouped together for both safety and efficacy primary analyses. HFS was reported in 31 patients (19.6%) and its first presentation occurred at a median of 72 days (range 19-209 days). Grade 3 HFS developed in 6.3, 5.2, 3.7 and 2.4%, of patients receiving ECX, DCX, EOX or CX chemotherapy regimen, respectively. Capecitabine dose reduction/discontinuation due to HFS was required in 5.7% of patients (9/158). The most common (10%) grade 3-4 treatment-related AEs were neutropenia (15.2%), asthenia (12.0%) and diarrhoea (11.4%).A moderate incidence of HFS was reported in patients treated with capecitabine, which generally presented late and required dose reduction in1/3 of patients. The results suggest that capecitabine may be useful in combination with standard fluorouracil-based regimens in patients with advanced and/or metastatic gastric cancer with favourable safety profile.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
Organoplatinum Compounds
medicine.medical_treatment
Deoxycytidine
Capecitabine
Stomach Neoplasms
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Humans
Medicine
Neoplasm Metastasis
Aged
Epirubicin
Chemotherapy
integumentary system
business.industry
Incidence
Incidence (epidemiology)
General Medicine
Middle Aged
Hand-Foot Syndrome
Oxaliplatin
Clinical trial
Regimen
Treatment Outcome
Fluorouracil
Female
Cisplatin
business
medicine.drug
Subjects
Details
- ISSN :
- 16993055 and 1699048X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Oncology
- Accession number :
- edsair.doi.dedup.....1ba45b353883bbb357ea027bd017ef04