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Karyotypic changes detected by comparative genomic hybridization in a stillborn infant with chorioangioma and liver hemangioma
- Source :
- Birth defects research. Part A, Clinical and molecular teratology. 79(3)
- Publication Year :
- 2007
-
Abstract
- BACKGROUND: Placental hemangioma (chorioangioma) and congenital hemangioma are relatively common tumors, which on rare occasions may occur together. Very little is known about the pathogenetic mechanisms underlying these lesions. CASE: Herein we describe a rare case of a stillborn infant with chorioangioma, placental mesenchymal dysplasia, and liver cavernous hemangioma. In addition, we present the findings of the karyotype analysis of these lesions, which was done with the bacterial artificial chromosome arrays using the comparative genomic hybridization method. The chromosomal abnormalities that we found were deletions at 2q13 and 7p21.1 and were common to both placental and liver lesions. CONCLUSIONS: None of the identified chromosomal aberrations have been previously associated with chorioangiomas or hemangiomas. Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital hemangiomas and mesenchymal dysplasia. Birth Defects Research (Part A) 2007. © 2006 Wiley-Liss, Inc.
- Subjects :
- Embryology
Pathology
medicine.medical_specialty
Chromosomes, Artificial, Bacterial
Placenta Diseases
Biology
Placental Mesenchymal Dysplasia
Pathogenesis
Placental Hemangioma
Pregnancy
medicine
Humans
Congenital Hemangioma
Chromosome Aberrations
Bacterial artificial chromosome
Liver Neoplasms
Infant, Newborn
Nucleic Acid Hybridization
Karyotype
General Medicine
Stillbirth
eye diseases
Hemangioma, Cavernous
Chromosomes, Human, Pair 2
Karyotyping
Pediatrics, Perinatology and Child Health
Liver Hemangioma
Female
sense organs
Hemangioma
Chromosomes, Human, Pair 7
Developmental Biology
Comparative genomic hybridization
Subjects
Details
- ISSN :
- 15420752
- Volume :
- 79
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Birth defects research. Part A, Clinical and molecular teratology
- Accession number :
- edsair.doi.dedup.....1ba08fa613da4d3b1605ed83c9978814