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Seroprevalence of Yellow fever, Chikungunya, and Zika virus at a community level in the Gambella Region, South West Ethiopia
- Source :
- PLoS ONE, Vol 16, Iss 7, p e0253953 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Yellow fever (YF), Chikungunya (CHIK), and Zika(ZIK) are among re-emerging arboviral diseases of major public health concern. Despite the proximity of the Gambella Region to South Sudan where arboviral cases have been recorded repeatedly the current epidemiological situation is unclear in this part of southwest Ethiopia. Therefore, we conducted a community-based seroprevalence survey of YF virus (YFV), CHIK virus (CHIKV), and ZIK virus (ZIKV) infections in two selected districts. A cross-sectional study was conducted in two locations of the Gambella region (Lare and Itang) to investigate the seroprevalence of these viruses’ infections. Blood samples were collected from the study participants and screened for IgG antibodies specific to YFV and CHIKV infections using enzyme-linked immunosorbent assays (ELISA). For the detection of ZIKV specific IgG antibodies, Blockade-of-binding ELISA was used. Data were analyzed using the STATA version 13.1 Softwares. A total of 150 individuals (96 males and 54 females, age ranging from 18 to 65 years, mean age ± SD = 35.92 ± 10.99) participated and provided blood samples. Among the 150 samples 135, 90, and 150 were screened for YFV, CHIKV, and ZIKV, respectively. Hence, 2.9% (95% CI: 1.1–7.7%), 15.6% (95% CI: 9.3–24.8%), and 27.3% (95% CI: 20.7–35.3%) of samples tested positive for IgG antibodies to YFV, CHIKV, and ZIKV infections, respectively. Among the individual seropositive for ZIKV, YFV and CHIKV, only six, one and three had a history of residence outside the Gambella region respectively. Agro-pastoral occupation was significantly associated with a higher prevalence of IgG against CHIKV (AOR = 14.17; 95%CI: 2.30, 87.30) and residency in the Lare district (AOR = 11; 95%CI: 3.31, 39.81) was found to be significantly associated with a higher prevalence of IgG against ZIKV. Our findings revealed the occurrence of YFV, CHIKV and ZIKV infections in the study locations.
- Subjects :
- Male
RNA viruses
Viral Diseases
Physiology
Pathology and Laboratory Medicine
medicine.disease_cause
Biochemistry
Zika virus
Geographical Locations
Medical Conditions
0302 clinical medicine
Residence Characteristics
Seroepidemiologic Studies
Immune Physiology
Epidemiology
Medicine and Health Sciences
030212 general & internal medicine
Chikungunya
Enzyme-Linked Immunoassays
South Sudan
Travel
Chikungunya Virus
Immune System Proteins
Multidisciplinary
Geography
biology
Zika Virus Infection
Yellow fever
Middle Aged
Infectious Diseases
Medical Microbiology
Arboviral Infections
Viral Pathogens
Viruses
Medicine
Female
Pathogens
Research Article
Neglected Tropical Diseases
Adult
medicine.medical_specialty
Adolescent
Alphaviruses
Science
Immunology
030231 tropical medicine
Research and Analysis Methods
Microbiology
Antibodies
Virus
Togaviruses
Young Adult
03 medical and health sciences
Yellow Fever
medicine
Humans
Seroprevalence
Immunoassays
Microbial Pathogens
Aged
Community level
Biology and life sciences
Flaviviruses
business.industry
Organisms
Proteins
Chikungunya Infection
Zika Virus
Specific igg
Tropical Diseases
medicine.disease
biology.organism_classification
Virology
Immunoglobulin G
People and Places
Africa
Immunologic Techniques
Chikungunya Fever
Ethiopia
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....1b9f73bc88c6aa841c7174bc747d347c