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Renal inflammation and injury are associated with lymphangiogenesis in hypertension
- Source :
- American journal of physiology. Renal physiology. 312(5)
- Publication Year :
- 2016
-
Abstract
- Lymphatic vessels are vital for the trafficking of immune cells from the interstitium to draining lymph nodes during inflammation. Hypertension is associated with renal infiltration of activated immune cells and inflammation; however, it is unknown how renal lymphatic vessels change in hypertension. We hypothesized that renal macrophage infiltration and inflammation would cause increased lymphatic vessel density in hypertensive rats. Spontaneously hypertensive rats (SHR) that exhibit hypertension and renal injury (SHR-A3 strain) had significantly increased renal lymphatic vessel density and macrophages at 40 wk of age compared with Wistar-Kyoto (WKY) controls. SHR rats that exhibit hypertension but minimal renal injury (SHR-B2 strain) had significantly less renal lymphatic vessel density compared with WKY rats. The signals for lymphangiogenesis, VEGF-C and its receptor VEGF-R3, and proinflammatory cytokine genes increased significantly in the kidneys of SHR-A3 rats but not in SHR-B2 rats. Fischer 344 rats exhibit normal blood pressure but develop renal injury as they age. Kidneys from 24-mo- and/or 20-mo-old Fischer rats had significantly increased lymphatic vessel density, macrophage infiltration, VEGF-C and VEGF-R3 expression, and proinflammatory cytokine gene expression compared with 4-mo-old controls. These data together demonstrate that renal immune cell infiltration and inflammation cause lymphangiogenesis in hypertension- and aging-associated renal injury.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Physiology
government.form_of_government
Vascular Endothelial Growth Factor C
Inflammation
Blood Pressure
030204 cardiovascular system & hematology
Kidney
Rats, Inbred WKY
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
Species Specificity
Rats, Inbred SHR
Lymphatic vessel
medicine
Animals
Lymphangiogenesis
Lymphatic Vessels
Nephritis
business.industry
Macrophages
Age Factors
medicine.disease
Vascular Endothelial Growth Factor Receptor-3
Rats, Inbred F344
Lymphatic Endothelium
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
Lymphatic system
Hypertension
government
cardiovascular system
Cytokines
medicine.symptom
Inflammation Mediators
business
Infiltration (medical)
Research Article
Subjects
Details
- ISSN :
- 15221466
- Volume :
- 312
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- American journal of physiology. Renal physiology
- Accession number :
- edsair.doi.dedup.....1b834f04d878b2c3046a8c28d3092e94