Influences of Helicobacter pylori on serum pepsinogen concentrations in dialysis patients

Background. Patients with impaired renal function have been known to have elevated concentrations of serum pepsinogens, which are raised by Helicobacter pylori infection of the stomach. The present study was performed to examine the effect of H. pylori infection on serum pepsinogen concentrations in dialysis patients. Methods. Forty nine patients on dialysis and 48 subjects with no known kidney disease were examined for upper gastroduodenal endoscopy, H. pylori infection and serum concentrations of pepsinogen I and II. The status of H. pylori infection was evaluated from results of a urease test, histology and culture of biopsy specimens of the gastric mucosa. Serum pepsinogen levels were measured by radioimmunoassay. Results. Serum concentrations of pepsinogen I and II were elevated in the dialysis patients in comparison with those in the controls (277.4±24.2 vs 52.6±4.0 pg/ml, P