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Whole-Body Regeneration in the Lobate Ctenophore Mnemiopsis leidyi
- Source :
- Genes, Genes, Vol 12, Iss 867, p 867 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus Beroe having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, Mnemiopsis leidyi, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. M. leidyi’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration.
- Subjects :
- 0301 basic medicine
Lineage (evolution)
Asexual reproduction
Review
QH426-470
Genome
Mnemiopsis leidyi
03 medical and health sciences
0302 clinical medicine
ctenophore
Genetics
Animals
Genetics (clinical)
biology
Mnemiopsis
Phylum
Regeneration (biology)
Ctenophora
biology.organism_classification
Regenerative process
030104 developmental biology
Evolutionary biology
regeneration
Whole body
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20734425
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Genes
- Accession number :
- edsair.doi.dedup.....1b712cc8105b4e6c8bf4080303742d52