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The Less Known Cyclins—Uncovered
- Source :
- Applied Sciences, Vol 11, Iss 2320, p 2320 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Cyclins belong to a group of proteins that are cyclically produced and destructed in a cell. Cyclins are a family of proteins that are a key component of the cell cycle regulating system, which level of expression depends on the phase of the cycle. Cyclins regulate the activity of cyclin-dependent kinases (Cdk), thanks to which they influence the length of individual phases of the cell cycle and also determine whether the cell can enter the next life stage. Proper expression of cyclins plays an important role in processes such as proliferation, transcription, DNA repair and cell differentiation. However, dysregulation of their expression is one of the most important disorders leading to the development of different types of cancer, which suggests that cyclins can be defined as a prognostic marker. Currently, we may distinguish >10 members of the cyclins family participating in the division of human cells. The group of less known cyclins includes C, F, G, H, I, J, K, L, M, O, T and Y cyclins. The present report demonstrates the current state of knowledge considering less known cyclins and their role in normal and cancer cells.
- Subjects :
- 0301 basic medicine
DNA repair
Cellular differentiation
Cell
lcsh:Technology
lcsh:Chemistry
03 medical and health sciences
0302 clinical medicine
Cyclin-dependent kinase
medicine
cancer
General Materials Science
lcsh:QH301-705.5
Instrumentation
Cyclin
Fluid Flow and Transfer Processes
biology
lcsh:T
Kinase
Process Chemistry and Technology
General Engineering
Cell cycle
lcsh:QC1-999
Computer Science Applications
Cell biology
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
lcsh:TA1-2040
030220 oncology & carcinogenesis
Cancer cell
biology.protein
cell cycle
lcsh:Engineering (General). Civil engineering (General)
cyclins
lcsh:Physics
Subjects
Details
- ISSN :
- 20763417
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Applied Sciences
- Accession number :
- edsair.doi.dedup.....1b6804e8702b87f51a76759b3ceac0a0
- Full Text :
- https://doi.org/10.3390/app11052320