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Effect of physical activity on pulse wave velocity in elderly subjects with normal glucose, prediabetes or Type 2 Diabetes
- Source :
- Scientific Reports, Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018), CEU Repositorio Institucional, Fundación Universitaria San Pablo CEU (FUSPCEU)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.nature.com/articles/s41598-018-25755-4 Este artículo fue presentado en parte en el 77th Scientific Sessions of the American Diabetes Association, June 9-13, 2017, San Diego, California, USA. Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks. (cf)PWV values in subjects with impaired glucose metabolism (IGM) and T2D were higher than in normal glycemic subjects (P < 0.001). PA, fasting and 2 h glucose and HbA1c correlated significantly with (cf)PWV, but HDL or LDL cholesterol did not. The 2 h glucose, heart rate and alcohol consumption in T2D subjects had independent effects on (cf)PWV in multiple regression analysis. T2D and IGM were significantly associated to (cf)PWV. Interestingly, lipids did not have an additional effect on (cf)PWV. Subjects walking more than 10 000 steps/day had 0.2 m/s lower (cf)PWV than those walking less than 6000 steps/day. Presence of T2D, elevated heart rate and alcohol consumption in males were associated with increased aortic stiffening in elderly subjects.
- Subjects :
- Blood Glucose
Male
Exercise - Physiological aspects
lcsh:Medicine
Type 2 diabetes
030204 cardiovascular system & hematology
Cohort Studies
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Prediabetes
lcsh:Science
Pulse wave velocity
Multidisciplinary
Enfermedades cardiovasculares - Factores de riesgo
Pulse - Mensuration
Exercise Therapy
Cardiovascular Diseases
cardiovascular system
Cardiology
Female
Diabetes
Presión sanguínea - Medición
Blood Flow Velocity
circulatory and respiratory physiology
Pulso - Medición
medicine.medical_specialty
030209 endocrinology & metabolism
Pulse Wave Analysis
Ritmo cardíaco - Medición
Article
Prediabetic State
03 medical and health sciences
Vascular Stiffness
Internal medicine
Diabetes mellitus
Heart rate
medicine
Humans
cardiovascular diseases
Aged
Glycemic
Ejercicio físico - Aspectos fisiológicos
Cardiovascular system - Diseases - Risk factors
Cholesterol
business.industry
lcsh:R
medicine.disease
Diabetes Mellitus, Type 2
chemistry
Case-Control Studies
Arterial stiffness
lcsh:Q
business
Blood pressure - Measurement
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....1b5827b3f76fff65a897441e1d012688