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Polarity in ciliate models: from cilia to cell architecture
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Frontiers in Cell and Developmental Biology, Vol 7 (2019), Frontiers in Cell and Developmental Biology
- Publication Year :
- 2019
- Publisher :
- Frontiers Media, 2019.
-
Abstract
- Tetrahymena and Paramecium are highly differentiated unicellular organisms with elaborated cortical patterns showing a regular arrangement of hundreds to thousands of basal bodies in longitudinal rows that extend from the anterior to the posterior region of the cell. Thus both ciliates exhibit a permanent antero–posterior axis and left–right asymmetry. This cell polarity is reflected in the direction of the structures nucleated around each basal body such as the ciliary rootlets. Studies in these ciliates showed that basal bodies assemble two types of cilia, the cortical cilia and the cilia of the oral apparatus, a complex structure specialized in food capture. These two cilia types display structural differences at their tip domain. Basal bodies possessing distinct compositions creating specialized landmarks are also present. Cilia might be expected to express and transmit polarities throughout signaling pathways given their recognized role in signal transduction. This review will focus on how local polarities in basal bodies/cilia are regulated and transmitted through cell division in order to maintain the global polarity and shape of these cells and locally constrain the interpretation of signals by different cilia. We will also discuss ciliates as excellent biological models to study development and morphogenetic mechanisms and their relationship with cilia diversity and function in metazoans.
- Subjects :
- 0301 basic medicine
Oral apparatus
Cell division
PEst-UID/EEA/00066/2013
Review
Biology
IPL/2019/MOONOFCILI/ESTeSL
ciliates cortex
Cell and Developmental Biology
03 medical and health sciences
0302 clinical medicine
Basal bodies
Cell polarity
Basal body
Paramecium
Cilia
lcsh:QH301-705.5
Ciliate
Ciliates cortex
Cilium
IPL/2017/CILIOPAT/ESTeSL
Tetrahymena
cilia
Cell Biology
PEst-OE/QUI/UI0612/2013
biology.organism_classification
Cell patterning
Signaling
Cell biology
cell patterning
cell polarity
030104 developmental biology
lcsh:Biology (General)
030220 oncology & carcinogenesis
basal bodies
AFM
signaling
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Frontiers in Cell and Developmental Biology, Vol 7 (2019), Frontiers in Cell and Developmental Biology
- Accession number :
- edsair.doi.dedup.....1b4e42bde6a8b632f6d145c1803c1df8