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High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania

Authors :
Nina Langeland
Bushir S. Tamim
Maulidi Fataki
Bjørn Blomberg
Roland Jureen
Karim Manji
Samwel Y. Maselle
Viola Msangi
Marit Gjerde Tellevik
Willy Urassa
Davis Mwakagile
Source :
Journal of clinical microbiology. 43(2)
Publication Year :
2005

Abstract

Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.

Details

ISSN :
00951137
Volume :
43
Issue :
2
Database :
OpenAIRE
Journal :
Journal of clinical microbiology
Accession number :
edsair.doi.dedup.....1b4a4ddc1b40601abe20eb08b2e6b9d9