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High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania
- Source :
- Journal of clinical microbiology. 43(2)
- Publication Year :
- 2005
-
Abstract
- Extended-spectrum beta-lactamases (ESBLs) were present in high proportions of Escherichia coli (25% [9 of 36]) and Klebsiella pneumoniae isolates (17% [9 of 52]) causing pediatric septicemia at a tertiary hospital in Tanzania. Patients with septicemia due to ESBL-producing organisms had a significantly higher fatality rate than those with non-ESBL isolates (71% versus 39%, P = 0.039). This is the first report of the CTX-M-15 genotype of ESBLs on the African continent and the first observation of SHV-12 genotype in an isolate of Salmonella enterica serotype Newport.
- Subjects :
- Microbiology (medical)
Serotype
Male
Klebsiella pneumoniae
Bacteremia
medicine.disease_cause
Tanzania
beta-Lactamases
Microbiology
Emerging and Re-emerging Infectious Diseases
Enterobacteriaceae
Genotype
Case fatality rate
medicine
polycyclic compounds
Escherichia coli
Humans
biology
Enterobacteriaceae Infections
Infant, Newborn
Infant
Salmonella enterica
Bacteriology
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Virology
Child, Preschool
bacteria
Female
Subjects
Details
- ISSN :
- 00951137
- Volume :
- 43
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of clinical microbiology
- Accession number :
- edsair.doi.dedup.....1b4a4ddc1b40601abe20eb08b2e6b9d9