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Endogenous sodium-potassium-chloride cotransport inhibitor in congestive heart failure
- Source :
- Journal of the American College of Cardiology. 28(6):1464-1470
- Publication Year :
- 1996
- Publisher :
- Elsevier BV, 1996.
-
Abstract
- Objectives. This study sought to evaluate the relation, if any, between fluid overload in congestive heart failure (CHF) and a newly discovered endogenous natriuretic factor acting like loop diuretic drugs: contransport inhibitory factor (CIF).Background. The humoral mechanisms regulating volume overload in CHF are not fully understood. Therefore, we investigated whether there is a role for CIF in this pathologic condition.Methods. Plasma and urinary CIF levels were investigated in 23 patients with chronic CHF and compared with changes in plasma atrial natriuretic peptide (ANP). Twelve patients without CHF served as control subjects.Results. CHF was associated with a highly significant threefold increase in both plasma CIF levels (mean ± SD 7.10 ± 3.01 vs. 2.28 ± 0.92 U/ml, p < 0.0001) and urinary CIF excretion (7,849 ± 3,600 vs. 2,351 ± 1,297 U/day, p < 0.0001) with respect to patients without CHF. CIF increased as a function of impairment in left ventricular ejection fraction (r = −0.703, p < 0.0001) and the severity of clinical status. Plasma ANP was also increased in patients with CHF, although to a lesser extent (68%, p = 0.0501) than plasma CIF, and was also significantly correlated with left ventricular ejection fraction (r = −0.552, p = 0.0004).Conclusions. Plasma and urinary CIF activities were strongly and very significantly increased in chronic CHF. In addition to ANP, this long-term natriuretic agent may be of potential importance in reducing fluid overload in CHF.
- Subjects :
- Adult
Male
medicine.medical_specialty
Sodium-Potassium-Chloride Symporters
medicine.drug_class
Urinary system
Sodium
Volume overload
chemistry.chemical_element
Endogeny
Biological Factors
Chlorides
Atrial natriuretic peptide
Internal medicine
medicine
Humans
cardiovascular diseases
Aged
Heart Failure
business.industry
Middle Aged
Loop diuretic
medicine.disease
Endocrinology
chemistry
Heart failure
Potassium
cardiovascular system
Cardiology
Female
Carrier Proteins
business
Cotransporter
Cardiology and Cardiovascular Medicine
Atrial Natriuretic Factor
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 28
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....1b4843a5cc75709553af5a90a48abe22
- Full Text :
- https://doi.org/10.1016/s0735-1097(96)00339-7