Back to Search
Start Over
Emtricitabine triphosphate in dried blood spots is a predictor of viral suppression in HIV infection and reflects short-term adherence to antiretroviral therapy
- Source :
- Journal of Antimicrobial Chemotherapy. 74:1395-1401
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- BACKGROUND: Emtricitabine triphosphate (FTC-TP), the phosphorylated anabolite of emtricitabine, can be quantified in dried blood spots (DBS). We evaluated FTC-TP in DBS as a predictor of viral suppression and evaluated self-reported adherence as a predictor of FTC-TP. METHODS: Persons living with HIV (PLWH) on an FTC-containing regimen were prospectively recruited. A DBS and HIV viral load were obtained during routine clinical visits. Self-reported adherence for 3 days, 30 days and 3 months was captured. Generalized estimating equations were used to estimate the adjusted odds ratio (aOR) of viral suppression for quantifiable FTC-TP versus below the limit of quantification (BLQ). The utility of self-reported adherence to predict quantifiable FTC-TP was assessed by calculating the area under receiver operating characteristic (ROC) curve. RESULTS: One thousand one hundred and fifty-four person-visits from 514 participants who had DBS assayed for FTC-TP were included in the analysis. After adjusting for age, gender, race, BMI, ART class, ART duration, estimated glomerular filtration rate and CD4+ T cell count, the aOR (95% CI) for viral suppression for quantifiable FTC-TP versus BLQ was 7.2 (4.3–12.0; P
- Subjects :
- Adult
Male
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Anti-HIV Agents
030106 microbiology
Renal function
HIV Infections
Emtricitabine
Medication Adherence
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Humans
Medicine
Pharmacology (medical)
Prospective Studies
030212 general & internal medicine
Viral suppression
Generalized estimating equation
Original Research
Pharmacology
Receiver operating characteristic
business.industry
Odds ratio
Middle Aged
Viral Load
Regimen
Infectious Diseases
Female
Dried Blood Spot Testing
Self Report
business
Viral load
medicine.drug
Subjects
Details
- ISSN :
- 14602091 and 03057453
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Journal of Antimicrobial Chemotherapy
- Accession number :
- edsair.doi.dedup.....1b46157861d7c93a05719b70cd0a27e4