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Magnesium sulfate administered via continuous intravenous infusion in pediatric patients with refractory wheezing
- Source :
- Journal of Critical Care. 17:255-258
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- To evaluate the dosing and safety of intravenous magnesium sulfate administered via continuous infusion for refractory wheezing.All patients admitted to the pediatric intensive care unit (PICU) between January 1998 and March 2001 who were prescribed magnesium sulfate via continuous infusion were identified via retrospective chart review. The patient's medical history, demographic data, vital signs, magnesium dosing history, and concurrent medications were recorded.Forty PICU patients represent our study population. The mean age was 82.6 +/- 64.6 mo; 18 patients were boys.The mean magnesium loading dose (mg/kg) was 29.6 +/- 13.2 with a mean infusion dose (mg/kg/h) of 18.4 +/- 6.5 with a significant difference in dosing noted between patients weighing less than 30 kg and those with a higher weight. The mean magnesium loading dose (mg/kg) in the less than 30 kg group was 35.3 +/- 12.7 compared with 21.9 +/- 9.9 in the higher weight group (P.05). Mean infusion doses (mg/kg/h) were 21.6 +/- 6 and 14.6 +/- 4.2, respectively (P.05). There was no significant difference between the mean concentrations (mg/dL) reported between the 2 groups (less than 30 kg group = 3.9 +/- 0.6; higher weight group = 3.6 +/- 0.5). All patients received nebulized albuterol, ipratropium, and intravenous methylprednisolone before magnesium therapy. Aminophylline and ketamine were prescribed to 28 and 4 patients, respectively. No cardiovascular adverse effects were noted during magnesium therapy.For the treatment of refractory wheezing, intravenous magnesium sulfate administered via continuous infusion represents a safe mode of drug delivery.
- Subjects :
- Male
Adolescent
Vital signs
chemistry.chemical_element
Intensive Care Units, Pediatric
Critical Care and Intensive Care Medicine
Loading dose
Magnesium Sulfate
Refractory
Humans
Medicine
Medical history
Dosing
Child
Infusions, Intravenous
Respiratory Sounds
Retrospective Studies
Pediatric intensive care unit
business.industry
Magnesium
Infant
Asthma
United States
Bronchodilator Agents
chemistry
Child, Preschool
Anesthesia
Population study
Female
business
Subjects
Details
- ISSN :
- 08839441
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Critical Care
- Accession number :
- edsair.doi.dedup.....1b3ccb1dce3d625f732e2b6a6fbcb378