Back to Search
Start Over
Prenylated Diphenyl Ethers from the Marine Algal-Derived Endophytic Fungus Aspergillus tennesseensis
- Source :
- Molecules, Volume 23, Issue 9, Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules, Vol 23, Iss 9, p 2368 (2018)
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Considerable attention has been paid to marine derived endophytic fungi, owing to their capacity to produce novel secondary metabolites with potent bioactivities. In this study, two new compounds with a prenylated diphenyl ether structure&mdash<br />diorcinol L (1) and (R)-diorcinol B (2)&mdash<br />were isolated from the marine algal-derived endophytic fungus Aspergillus tennesseensis, along with seven known compounds: (S)-diorcinol B (3), 9-acetyldiorcinol B (4), diorcinol C (5), diorcinol D (6), diorcinol E (7), diorcinol J (8), and a dihydrobenzofuran derivative 9. Their structures were elucidated by extensive NMR spectroscopy studies. Compound 2 represents the first example of an R-configuration in the prenylated moiety. All these isolated compounds were examined for antimicrobial and cytotoxic activities. Compounds 1&ndash<br />9 exhibited antimicrobial activities against some human- and plant-pathogenic microbes with MIC values ranging from 2 to 64 &mu<br />g/mL. Moreover, compound 9 displayed considerable inhibitory activity against the THP-1 cell line in vitro, with an IC50 value of 7.0 &mu<br />g/mL.
- Subjects :
- Aquatic Organisms
Stereochemistry
Proton Magnetic Resonance Spectroscopy
Pharmaceutical Science
Microbial Sensitivity Tests
01 natural sciences
Article
Plant use of endophytic fungi in defense
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
Cell Line, Tumor
Drug Discovery
Endophytes
Humans
Moiety
Carbon-13 Magnetic Resonance Spectroscopy
Physical and Theoretical Chemistry
Prenylation
antimicrobial activity
Bacteria
secondary metabolites
010405 organic chemistry
Phenyl Ethers
Organic Chemistry
Diphenyl ether
Aspergillus tennesseensis
Nuclear magnetic resonance spectroscopy
Antimicrobial
In vitro
0104 chemical sciences
marine-derived fungi
010404 medicinal & biomolecular chemistry
Aspergillus
chemistry
Chemistry (miscellaneous)
cytotoxicity
Molecular Medicine
diphenyl ethers
Derivative (chemistry)
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....1b3a9301013981a2249faec3c83ed55e