Transient hemiparesis associated with monoclonal CD3 antibody (OKT3) therapy

Authors :: John D. Osterman
Jacques Lemire
Vivian Reznik
Doris A. Trauner
Source :: Pediatric Neurology. 9:482-484
Publication Year :: 1993
Publisher :: Elsevier BV, 1993.
Abstract: OKT3 therapy for prevention or reversal of allograft rejection has been associated with a constellation of acute systemic side effects, defined as an OKT3 first-dose reaction. Specific neurologic syndromes, including aseptic meningitis and diffuse encephalitis, have also been observed. This report describes a 12-year-old girl with steroid-resistant renal allograft rejection who developed hemiparesis associated with initiation of OKT3 therapy.