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Blood urea in preterm infants on routine parenteral nutrition: A multiple linear regression analysis
- Publication Year :
- 2021
-
Abstract
- Summary Background Blood urea is considered a marker of amino acid utilization in preterm infants on routine parenteral nutrition. However, the association between blood urea and intravenous amino acid intake remains debated. Aims To evaluate the association between blood urea and both nutrition and clinical data, in a large cohort of preterm infants. Methods Consecutively admitted preterm infants with a gestational age of less than 32 weeks and a birth weight lower than 1250 g on routine parenteral nutrition from the first hour of life were studied. Clinical and nutrition data collected hourly during the hospitalization were used in multiple linear regression analysis. Results We studied 674 patients and 1863 blood urea determinations. Blood urea concentration was positively associated with blood creatinine concentration, intravenous amino acid intake, patent ductus arteriosus and respiratory distress syndrome, and negatively associated with intravenous non-protein energy intakes, daily weight change, gestational age, being small for gestational age, antenatal steroids therapy and reverse flow in the umbilical artery (p Conclusions From a nutrition perspective, in our large cohort of small preterm infants blood urea was positively correlated with intravenous amino acid intake and negatively correlated with intravenous non-protein energy intake. This is in line with current knowledge in human physiology and suggest that a reduction of intravenous amino acid intake based on blood urea concentrations was justified.
- Subjects :
- Male
0301 basic medicine
Birth weight
Physiology
Gestational Age
030209 endocrinology & metabolism
Critical Care and Intensive Care Medicine
Eating
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
medicine.artery
Blood urea
Birth Weight
Humans
Urea
Medicine
Amino Acids
Infant Nutritional Physiological Phenomena
Ductus Arteriosus, Patent
Respiratory Distress Syndrome, Newborn
030109 nutrition & dietetics
Nutrition and Dietetics
Respiratory distress
business.industry
Weight change
Infant, Newborn
Gestational age
Preterm infants
Umbilical artery
medicine.disease
Parenteral nutrition
Amino acid
chemistry
Creatinine
Infant, Small for Gestational Age
Multivariate Analysis
Linear Models
Small for gestational age
Female
business
Infant, Premature
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1b272427e144aeb0d531a6b12a9106b7