Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is recognized as a heterogeneous disease.[1][1] Although the clinical staging systems (Rai et al[2][2] and Binet et al[3][3]) provide useful methods of assessing patient prognosis, they do not provide an understanding of the basis of the heterogeneity. CLL cells