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Antibody response to feline herpesvirus-1 vaccination in healthy adult cats
- Source :
- Journal of Feline Medicine and Surgery. 22:329-338
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- ObjectivesVaccination against feline herpesvirus-1 (FHV-1) is recommended for all cats. However, it is unknown how adult healthy cats with different pre-vaccination antibodies respond to FHV-1 vaccination in the field. The aim of the study was to determine the prevalence of neutralising antibodies against FHV-1 in healthy adult cats and the response to FHV-1 vaccination within 28 days of vaccination.MethodsOne hundred and ten cats (⩾1 year of age) that had not received a vaccination within the past 12 months were vaccinated with a combined FHV-1 vaccine. Antibodies against FHV-1 were determined before vaccination (day 0), on day 7 and day 28 by serum neutralisation test. Uni- and multivariate statistical analyses were used to determine factors associated with the presence of pre-vaccination antibodies and response to vaccination.ResultsPre-vaccination neutralising antibody titres (⩾10) were present in 40.9% of cats (45/110; 95% confidence interval [CI] 32.2–50.3); titres were generally low (range 10–640). Antibody response to vaccination (⩾four-fold titre increase) was observed in 8.3% (9/109; 95% CI 4.2–15.1). Cats ⩾2 years of age were more likely to have pre-vaccination neutralising antibodies than cats aged between 1 and 2 years (odds ratio [OR] 24.619; P = 0.005). Cats from breeders were more likely to have pre-vaccination neutralising antibodies than privately owned cats (OR 7.070; P = 0.007). Domestic shorthair cats were more likely to have an at least four-fold titre increase vs purebred cats (OR 11.22; P = 0.027).Conclusions and relevanceMany cats have no detectable neutralising antibodies against FHV-1 despite previous vaccinations and fail to develop a ⩾four-fold titre increase after vaccination. This is likely because older cats and cats with a higher FHV-1 exposure risk are more likely to get infected with FHV-1 and thus to have FHV-1 neutralizing antibodies. Purebred cats more often fail to develop a ⩾four-fold titre increase after vaccination.
- Subjects :
- 040301 veterinary sciences
Antibodies, Viral
Cat Diseases
Active immunization
0403 veterinary science
03 medical and health sciences
Animals
Medicine
Varicellovirus
ddc:610
Small Animals
030304 developmental biology
0303 health sciences
CATS
biology
business.industry
Vaccination
Viral Vaccines
Herpesviridae Infections
04 agricultural and veterinary sciences
Virology
Antibody response
Cats
biology.protein
Feline herpesvirus
Antibody
business
FHV-1
active immunization
protection
MLV
Subjects
Details
- ISSN :
- 15322750 and 1098612X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of Feline Medicine and Surgery
- Accession number :
- edsair.doi.dedup.....1b1152311394d92ded6669bee4e54179