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Effects of bilateral olfactory bulbectomy on the anterior pituitary corticotropic cell activity in male rats

Authors :
Anne Marcilhac
Francis Hery
G Anglade
P. Siaud
Source :
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 31(7)
Publication Year :
1999

Abstract

Bilateral olfactory bulbectomy (OB) has drastic biochemical and behavioral effects and is often associated with an increase in plasma corticosterone concentrations. This experiment examined the effects of OB on adrenocorticotropin (ACTH) and corticosterone release under basal and stress conditions and on proopiomelanocortin (POMC) gene expression. Bulbectomy potentiated hypophysal ACTH and adrenal corticosterone release induced by ether stress but had no effect on ACTH release under basal conditions, despite a significant increase of circulating corticosterone. POMC gene expression was stronger (+60%) in OB rats than in sham-operated rats. These results suggest that olfactory bulbectomy substantially altered the negative feed-back exerted by glucocorticoids on anterior pituitary corticotropic cells in the male rat.

Details

ISSN :
00185043
Volume :
31
Issue :
7
Database :
OpenAIRE
Journal :
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Accession number :
edsair.doi.dedup.....1b0f18758dfce4a42ed4ec9a56d5f4ac