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Effects of bilateral olfactory bulbectomy on the anterior pituitary corticotropic cell activity in male rats
- Source :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 31(7)
- Publication Year :
- 1999
-
Abstract
- Bilateral olfactory bulbectomy (OB) has drastic biochemical and behavioral effects and is often associated with an increase in plasma corticosterone concentrations. This experiment examined the effects of OB on adrenocorticotropin (ACTH) and corticosterone release under basal and stress conditions and on proopiomelanocortin (POMC) gene expression. Bulbectomy potentiated hypophysal ACTH and adrenal corticosterone release induced by ether stress but had no effect on ACTH release under basal conditions, despite a significant increase of circulating corticosterone. POMC gene expression was stronger (+60%) in OB rats than in sham-operated rats. These results suggest that olfactory bulbectomy substantially altered the negative feed-back exerted by glucocorticoids on anterior pituitary corticotropic cells in the male rat.
- Subjects :
- Pomc gene
Male
endocrine system
medicine.medical_specialty
Pro-Opiomelanocortin
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Biochemistry
Feedback
Rats, Sprague-Dawley
chemistry.chemical_compound
Basal (phylogenetics)
Endocrinology
Anterior pituitary
Proopiomelanocortin
Adrenocorticotropic Hormone
Corticosterone
Pituitary Gland, Anterior
Internal medicine
Gene expression
Male rats
medicine
Animals
RNA, Messenger
biology
Biochemistry (medical)
General Medicine
Olfactory Bulb
Rats
medicine.anatomical_structure
chemistry
biology.protein
Corticotropic cell
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 00185043
- Volume :
- 31
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- Accession number :
- edsair.doi.dedup.....1b0f18758dfce4a42ed4ec9a56d5f4ac