Back to Search
Start Over
Influence of functional groups on the in vitro anticoagulant activity of chitosan sulfate
- Source :
- Carbohydrate Research. 338:483-489
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- A new method for the chemical modification of chitosan sulfate was used to prepare N-propanoyl-, N-hexanoyl- and N,O-quaternary substituted chitosan sulfate. Structural analysis by elemental analysis, FTIR, 13C NMR, and 1H NMR spectroscopy, and gel-permeation chromatography showed that these methods could conveniently be used for the introduction of functional groups. The influences of the acyl or quaternary groups on the anticoagulant activity of the polysaccharides were studied with respect to activated partial thromboplastin time (APTT) thrombin time (TT), and prothrombin time (PT). The propanoyl and hexanoyl groups increased the APTT activity, and the propanoyl groups also increased the TT anticoagulant activity slightly, while the N,O-quaternary chitosan sulfate showed only a slight TT coagulant activity.
- Subjects :
- Magnetic Resonance Spectroscopy
Time Factors
Acylation
Chitin
Thrombin time
Biochemistry
Analytical Chemistry
Chitosan
chemistry.chemical_compound
Spectroscopy, Fourier Transform Infrared
medicine
Humans
Blood Coagulation
Blood coagulation test
Prothrombin time
Chromatography
medicine.diagnostic_test
Chemistry
Organic Chemistry
Anticoagulants
Chemical modification
General Medicine
Nuclear magnetic resonance spectroscopy
Prothrombin Time
Partial Thromboplastin Time
Blood Coagulation Tests
circulatory and respiratory physiology
Partial thromboplastin time
Subjects
Details
- ISSN :
- 00086215
- Volume :
- 338
- Database :
- OpenAIRE
- Journal :
- Carbohydrate Research
- Accession number :
- edsair.doi.dedup.....1afc977092cca45a226313ce5baacc17