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Cellular Signal Transductions and Their Inhibitors Derived from Deep-Sea Organisms
- Source :
- Marine Drugs, Marine Drugs, Vol 19, Iss 205, p 205 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Not only physiological phenomena but also pathological phenomena can now be explained by the change of signal transduction in the cells of specific tissues. Commonly used cellular signal transductions are limited. They consist of the protein–tyrosine kinase dependent or independent Ras-ERK pathway, and the PI3K-Akt, JAK-STAT, SMAD, and NF-κB-activation pathways. In addition, biodegradation systems, such as the ubiquitin–proteasome pathway and autophagy, are also important for physiological and pathological conditions. If we can control signaling for each by a low-molecular-weight agent, it would be possible to treat diseases in new ways. At present, such cell signaling inhibitors are mainly looked for in plants, soil microorganisms, and the chemical library. The screening of bioactive metabolites from deep-sea organisms should be valuable because of the high incidence of finding novel compounds. Although it is still an emerging field, there are many successful examples, with new cell signaling inhibitors. In this review, we would like to explain the current view of the cell signaling systems important in diseases, and show the inhibitors found from deep-sea organisms, with their structures and biological activities. These inhibitors are possible candidates for anti-inflammatory agents, modulators of metabolic syndromes, antimicrobial agents, and anticancer agents.
- Subjects :
- cellular signal transduction
Aquatic Organisms
Cell signaling
Anti-Inflammatory Agents
Secondary Metabolism
Pharmaceutical Science
Antineoplastic Agents
SMAD
Review
Biology
01 natural sciences
Chemical library
Structure-Activity Relationship
03 medical and health sciences
chemistry.chemical_compound
Anti-Infective Agents
Drug Discovery
Animals
Humans
bioactive metabolite
deep-sea organisms
lcsh:QH301-705.5
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
030304 developmental biology
0303 health sciences
Molecular Structure
010405 organic chemistry
Kinase
Autophagy
Antimicrobial
anti-inflammatory agent
0104 chemical sciences
Cell biology
anticancer agent
lcsh:Biology (General)
chemistry
High incidence
Signal transduction
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Volume :
- 19
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Marine Drugs
- Accession number :
- edsair.doi.dedup.....1af7fcc3316cd7eb9419504f9aecaa8b