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Frequent Premature Atrial Contractions as a Poor Prognostic Factor in Cryptogenic Stroke Patients with Concomitant Non-Sustained Atrial Tachycardia
- Source :
- Yonsei Medical Journal
- Publication Year :
- 2020
- Publisher :
- Yonsei University College of Medicine, 2020.
-
Abstract
- In cryptogenic stroke patients, early detection of new-onset atrial fibrillation (AF) and recurrent stroke is required to prevent poor clinical outcomes. Therefore, we investigated the predictors of new-onset AF and recurrent stroke in cryptogenic stroke patients without previously diagnosed AF. In total, 390 patients who were diagnosed with stroke and non-sustained atrial tachycardia (NSAT) on 24-hour Holter monitoring were followed up to assess new-onset AF and recurrent stroke. The 5-year event-free survival as well as the predictors of recurrent stroke or new-onset AF were investigated. Based on receiver operating characteristic analysis, frequent premature atrial contractions (PACs) were defined as PACs >44 beats/day. The median follow-up period was 35 months. The composite event rate was 11.5%. In Kaplan-Meier analysis, the 5-year cumulative incidence of composite events was higher in cryptogenic stroke patients with frequent PACs than in those without frequent PACs. Multivariate analysis revealed that current smoking, increased left atrial volume index, and frequent PACs were poor prognostic predictors of composite event, and frequent PACs were an independent poor prognostic factor of new-onset AF in cryptogenic stroke patients. Therefore, frequent PACs might be associated with poor clinical outcomes (new-onset AF and recurrent stroke) in cryptogenic stroke patients with concomitant NSAT.
- Subjects :
- Male
medicine.medical_specialty
Prognostic factor
Cardiac & Cardiovascular Systems
Premature atrial contraction
recurrent stroke
clinical outcome
Cryptogenic stroke
030204 cardiovascular system & hematology
Brief Communication
03 medical and health sciences
0302 clinical medicine
Heart Rate
Tachycardia
Internal medicine
Atrial Fibrillation
Republic of Korea
medicine
Humans
Cumulative incidence
cardiovascular diseases
Stroke
Atrial tachycardia
Aged, 80 and over
business.industry
Incidence
Atrial fibrillation
Cerebral Infarction
General Medicine
Middle Aged
premature atrial contraction
Prognosis
medicine.disease
030220 oncology & carcinogenesis
Concomitant
Electrocardiography, Ambulatory
Cardiology
Female
Atrial Premature Complexes
medicine.symptom
business
Subjects
Details
- ISSN :
- 19762437 and 05135796
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Yonsei Medical Journal
- Accession number :
- edsair.doi.dedup.....1ae6da0e79a8745c7eb9fd0762f454f5