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Osteogenesis and angiogenesis properties of dental pulp cell on novel injectable tricalcium phosphate cement by silica doped

Authors :
Tsui-Hsien Huang
Ying-Fang Su
Chi-Chang Lin
Ming-Yung Chou
Ming-You Shie
Jaw-Ji Yang
Source :
Materials Science and Engineering: C. 42:672-680
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

β-Tricalcium phosphate (β-TCP) is an osteoconductive material in clinical. In this study, we have doped silica (Si) into β-TCP and enhanced its bioactive and osteostimulative properties. To check its effectiveness, a series of Si-doped with different ratios were prepared to make new bioactive and biodegradable biocomposites for bone repair. Formation of the diametral tensile strength, ions released and weight loss of cements was considered after immersion. In addition, we also examined the behavior of human dental pulp cells (hDPCs) cultured on Si-doped β-TCP cements. The results showed that setting time and injectability of the Si-doped β-TCP cements were decreased as the Si content was increased. At the end of the immersion point, weight losses of 30.1%, 36.9%, 48.1%, and 55.3% were observed for the cement doping 0%, 10%, 20%, and 30% Si into β-TCP cements, respectively. In vitro cell experiments show that the Si-rich cements promote human dental pulp cell (hDPC) proliferation and differentiation. However, when the Si-doped in the cement is more than 20%, the amount of cells and osteogenesis protein of hDPCs was stimulated by Si released from Si-doped β-TCP cements. The degradation of β-TCP and osteogenesis of Si gives a strong reason to believe that these Si-doped β-TCP cements may prove to be promising bone repair materials.

Details

ISSN :
09284931
Volume :
42
Database :
OpenAIRE
Journal :
Materials Science and Engineering: C
Accession number :
edsair.doi.dedup.....1ae4b3f683e3b362addfc7d4d31340d3
Full Text :
https://doi.org/10.1016/j.msec.2014.05.038