Back to Search
Start Over
Lipid-based nanosystems for CD44 targeting in cancer treatment: recent significant advances, ongoing challenges and unmet needs
- Source :
- Nanomedicine. 11:1865-1887
- Publication Year :
- 2016
- Publisher :
- Future Medicine Ltd, 2016.
-
Abstract
- Extensive experimental evidence demonstrates the important role of hyaluronic acid (HA)-CD44 interaction in cell proliferation and migration, inflammation and tumor growth. Taking advantage of this interaction, the design of HA-modified nanocarriers has been investigated for targeting CD44-overexpressing cells with the purpose of delivering drugs to cancer or inflammatory cells. The effect of such modification on targeting efficacy is influenced by several factors. In this review, we focus on the impact of HA-modification on the characteristics of lipid-based nanoparticles. We try to understand how these modifications influence particle physicochemical properties, interaction with CD44 receptors, intracellular trafficking pathways, toxicity, complement/macrophage activation and pharmacokinetics. Our aim is to provide insight in tailoring particle modification by HA in order to design more efficient CD44-targeting lipid nanocarriers.
- Subjects :
- 0301 basic medicine
Biomedical Engineering
Medicine (miscellaneous)
Antineoplastic Agents
Bioengineering
Inflammation
02 engineering and technology
Development
Pharmacology
Unmet needs
03 medical and health sciences
Drug Delivery Systems
Nanocapsules
Neoplasms
Animals
Humans
Medicine
Macrophage
General Materials Science
Hyaluronic Acid
Receptor
biology
business.industry
CD44
Cancer
Lipid Metabolism
021001 nanoscience & nanotechnology
medicine.disease
Lipids
Cancer treatment
Hyaluronan Receptors
030104 developmental biology
Liposomes
biology.protein
Cancer research
Nanocarriers
medicine.symptom
0210 nano-technology
business
Subjects
Details
- ISSN :
- 17486963 and 17435889
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nanomedicine
- Accession number :
- edsair.doi.dedup.....1ae49131f0a43c52241e49a963d12ff1