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Opportunities and challenges of active immunotherapy in dogs with B-cell lymphoma: a 5-year experience in two veterinary oncology centers
- Source :
- Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019), Journal for Immunotherapy of Cancer
- Publication Year :
- 2019
-
Abstract
- Background Pet dogs spontaneously develop lymphoma. An anthracycline-based multidrug chemotherapy regimen represents the treatment cornerstone; however, cure is rarely achieved. We have been treating dogs with B-cell lymphoma with an autologous vaccine (APAVAC®) and CHOP-based chemotherapy since 2011. Methods To better characterize the safety and efficacy of APAVAC®, and to find the best candidates for immunotherapy, we designed a retrospective study on all dogs treated with chemo-immunotherapy to date and compared them with those dogs treated with chemotherapy only. All dogs were completely staged and re-staged at the end of treatment. The primary endpoint was the effectiveness of chemo-immunotherapy, measured as time to progression (TTP), lymphoma-specific survival (LSS), and 1-, 2-, and 3-year survival rates. The secondary objective was safety. Results Three hundred dogs were included: 148 (49.3%) received chemotherapy and 152 (50.7%) chemo-immunotherapy. Overall, the latter survived significantly longer (median LSS, 401 vs 220; P
- Subjects :
- Male
0301 basic medicine
Oncology
Cancer Research
Time Factors
Lymphoma
medicine.medical_treatment
Follicular lymphoma
Cancer immunotherapy
Veterinary oncology
Active immunotherapy
CHOP
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
Dog
Immunology and Allergy
Child
B-cell lymphoma
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
MZL
Tolerability
Child, Preschool
030220 oncology & carcinogenesis
Molecular Medicine
Female
Lymphoma, Large B-Cell, Diffuse
Research Article
medicine.medical_specialty
Prognosi
Immunology
lcsh:RC254-282
Autologous vaccine
DLBCL
Spontaneous cancer
03 medical and health sciences
Dogs
Internal medicine
medicine
Animals
Humans
dog, B-cell lymphoma, active immunotherapy
Pharmacology
Chemotherapy
business.industry
Immunotherapy, Active
medicine.disease
Regimen
030104 developmental biology
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-9 (2019), Journal for Immunotherapy of Cancer
- Accession number :
- edsair.doi.dedup.....1adc2caa4ff6cf9dfeaf5ac998660ef4