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Generation of Lung Epithelium from Pluripotent Stem Cells
- Source :
- Current Pathobiology Reports
- Publication Year :
- 2013
-
Abstract
- The understanding of key processes and signaling mechanisms in lung development has been mainly demonstrated through gain and loss of function studies in mice, while human lung development remains largely unexplored due to inaccessibility. Several recent reports have exploited the identification of key signaling mechanisms that regulate lineage commitment and restriction in mouse lung development, to direct differentiation of both mouse and human pluripotent stem cells towards lung epithelial cells. In this review, we discuss the recent advances in the generation of respiratory epithelia from pluripotent stem cells and the potential of these engineered cells for novel scientific discoveries in lung diseases and future translation into regenerative therapies.
- Subjects :
- Cancer Research
Embryonic stem cells
Airway epithelium
Pluripotential Stem Cells (WE Lowry, Section Editor)
Cystic fibrosis
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
medicine
Induced pluripotent stem cell
Molecular Biology
Lung
Loss function
030304 developmental biology
0303 health sciences
Lineage commitment
business.industry
Translation (biology)
Cell Biology
respiratory system
Embryonic stem cell
3. Good health
Cell biology
Pathobiology
Induced pluripotent stem cells
medicine.anatomical_structure
030220 oncology & carcinogenesis
Lung epithelium
Immunology
Respiratory epithelium
Lung development
business
Subjects
Details
- ISSN :
- 2167485X
- Volume :
- 1
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Current pathobiology reports
- Accession number :
- edsair.doi.dedup.....1adc20d4392df24d7f262d6b069556e3