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Application of a Collagen-Based Membrane and Chondroitin Sulfate-Based Hydrogel Adhesive for the Potential Repair of Severe Ocular Surface Injuries
- Source :
- Military Medicine. 179:686-694
- Publication Year :
- 2014
- Publisher :
- Oxford University Press (OUP), 2014.
-
Abstract
- This study was performed to evaluate the potential of a chondroitin sulfate-polyethylene glycol (CS-PEG) adhesive and collagen-based membrane (collagen vitrigel, CV) combination as a method to treat penetrating ocular injuries on the battlefield and to improve this method with two technologies: an antibiotic releasing CS-PEG adhesive and a corneal shaped CV. Burst testing using porcine cadaveric eyes, high-performance liquid chromatography, the Kirby-Bauer bacterial inhibition test, and CV implantations on the live and cadaveric rabbit eyes were performed. The ocular burst test showed CS-PEG adhesive could successfully repair 5-mm to 6-mm length wounds in the corneal and corneoscleral regions but would require CS-PEG + CV to treat larger wounds similar to those seen on the battlefield. In addition, high performance liquid chromatography and the Kirby-Bauer bacterial inhibition test presented evidence suggesting the vancomycin incorporated CS-PEG could inhibit Staphylococcus infection for 9 days. Furthermore, the curved CV showed an advantage by matching the corneal contour without any wrinkle formation. Although this pilot study showed a limited range of possible applications, we demonstrated that the combination of CS-PEG adhesive + CV is a promising method and the 2 technologies improve their applicability to the special demands of the battlefield.
- Subjects :
- Male
Staphylococcus aureus
Pathology
medicine.medical_specialty
Swine
High-performance liquid chromatography
Polyethylene Glycols
Eye injuries
chemistry.chemical_compound
Blast Injuries
Disk Diffusion Antimicrobial Tests
Vancomycin
Ophthalmology
Cadaver
medicine
Animals
Chondroitin
Chondroitin sulfate
Corneal Perforation
business.industry
Chondroitin Sulfates
Public Health, Environmental and Occupational Health
Hydrogels
Membranes, Artificial
General Medicine
medicine.disease
Eye Injuries, Penetrating
Anti-Bacterial Agents
chemistry
Self-healing hydrogels
Tissue Adhesives
Collagen
Rabbits
Adhesive
Cadaveric spasm
business
medicine.drug
Subjects
Details
- ISSN :
- 1930613X and 00264075
- Volume :
- 179
- Database :
- OpenAIRE
- Journal :
- Military Medicine
- Accession number :
- edsair.doi.dedup.....1ad1f6b7f8b476d30c942f1342090a00