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Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis
- Source :
- The Lancet. 335:1051-1055
- Publication Year :
- 1990
- Publisher :
- Elsevier BV, 1990.
-
Abstract
- 144 patients with severe rheumatoid arthritis from six centres were randomised to receive oral cyclosporin or placebo for 6 months. The initial daily dose of cyclosporin was 2·5 mg/kg, which was increased cautiously with monitoring of serum cyclosporin levels and creatinine; the mean stabilisation dose was 3·8 mg/kg. There were significant improvements in the cyclosporin-treated patients compared with the controls in the major outcomes of reduction of active joints (23% improvement), pain (24%), and functional status (16%); global improvement was 27%. In the cyclosporin group serum creatinine increased by a mean of 15·6 μmol/l and mean arterial blood pressure by 6·27 mm Hg; these increases were controlled in all but 2 patients by dose adjustment without withdrawal from the study.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Urology
Administration, Oral
Arthritis
Blood Pressure
Cyclosporins
Placebo
Severity of Illness Index
Drug Administration Schedule
Arthritis, Rheumatoid
Placebos
chemistry.chemical_compound
Activities of Daily Living
medicine
Humans
Multicenter Studies as Topic
In patient
Randomized Controlled Trials as Topic
Chemotherapy
Creatinine
business.industry
Low dose
General Medicine
Middle Aged
medicine.disease
Surgery
Blood pressure
chemistry
Rheumatoid arthritis
Drug Evaluation
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 01406736
- Volume :
- 335
- Database :
- OpenAIRE
- Journal :
- The Lancet
- Accession number :
- edsair.doi.dedup.....1ac804592ec3e23fc1bea096c2a6cc66