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Protective effect of astragaloside IV on cadmium-induced spermatogenesis microenvironment damage in rats
- Source :
- Systems Biology in Reproductive Medicine. 68:203-212
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- The previous study using Sertoli cells cultured in vitro has shown that the protective effects of astragaloside IV (AsIV) on cadmium (Cd)-induced damage to Sertoli cells and its membrane proteins. Yet, it is not known if AsIV has an equivalent effect on Cd-induced damage to the spermatogenesis microenvironment in rats. Using an in vivo model, Cd-induced damage to the spermatogenesis microenvironment and the protective effects of AsIV were studied. Eighteen male Sprague Dawley (SD) rats were randomly divided into three groups (n = 6/group): Cd group, CdA Cd: cadmium; SD: Sprague Dawley; ZO-1: zonal occludin-1; Cx43: connexin 43; BTB: blood-testis barrier; MAPKs: mitogen-activated protein kinases; OSP: oligodendrocyte-specific protein; Cxs: connexins; GJIC: gap junctional intercellular communication; ROS: reactive oxygen species; MDA: malondialdehyde; TGF: tumor growth factor; PBS: phosphate buffer saline; BSA: bovine serum albumin.
- Subjects :
- Male
Urology
Connexin
Pharmacology
Rats, Sprague-Dawley
chemistry.chemical_compound
Occludin
medicine
Animals
Bovine serum albumin
Spermatogenesis
chemistry.chemical_classification
Reactive oxygen species
Sertoli Cells
biology
Chemistry
Kinase
Body Weight
Saponins
Malondialdehyde
Sertoli cell
Triterpenes
Rats
medicine.anatomical_structure
Seminiferous tubule
Reproductive Medicine
Connexin 43
Claudins
biology.protein
Cadmium
Subjects
Details
- ISSN :
- 19396376 and 19396368
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Systems Biology in Reproductive Medicine
- Accession number :
- edsair.doi.dedup.....1ab7447dcb031272c8973a2f3cf6abbf