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Assessment of Cognitive Symptoms in Prodromal and Early Huntington Disease
- Source :
- PLoS Currents
- Publication Year :
- 2011
- Publisher :
- Public Library of Science (PLoS), 2011.
-
Abstract
- The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identify relevant symptom domains, including HD individuals, caregivers, and experts from a variety of fields, as well as knowledge gained from the analysis of data from ongoing large-scale studies in HD using existing clinical scales. This is an iterative process in which an ongoing series of field tests in prodromal (prHD) and early HD individuals provides the team with data on which to make decisions regarding which questions should undergo further development or testing and which should be excluded. We report here the development and assessment of the first iteration of interview questions aimed to assess cognitive symptoms in prHD and early HD individuals.
- Subjects :
- 0303 health sciences
medicine.medical_specialty
Cognitive Symptoms
business.industry
Medicine (miscellaneous)
Field tests
Disease
03 medical and health sciences
Huntington Disease
0302 clinical medicine
Multidisciplinary approach
Rating scale
medicine
Gene expansion
Functional ability
Psychiatry
business
030217 neurology & neurosurgery
030304 developmental biology
Subjects
Details
- ISSN :
- 21573999
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS Currents
- Accession number :
- edsair.doi.dedup.....1aac0599f5c79e3a0129b7be1d15fce1