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Uniqueness of the mechanism of protein import into the peroxisome matrix: Transport of folded, co-factor-bound and oligomeric proteins by shuttling receptors
- Source :
- Biochimica et Biophysica Acta-Molecular Cell Research, Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2006, 1763 (12), pp.1552-1564. ⟨10.1016/j.bbamcr.2006.08.037⟩
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Based on earlier suggestions that peroxisomes may have arisen from endosymbionts that later lost their DNA, it was expected that protein transport into this organelle would have parallels to systems found in other organelles of endosymbiont origin, such as mitochondria and chloroplasts. This review highlights three features of peroxisomal matrix protein import that make it unique in comparison with these other subcellular compartments - the ability of this organelle to transport folded, co-factor-bound and oligomeric proteins, the dynamics of the import receptors during the matrix protein import cycle and the existence of a peroxisomal quality-control pathway, which insures that the peroxisome membrane is cleared of cargo-free receptors.
- Subjects :
- Cytoplasm
Protein Folding
Saccharomyces cerevisiae Proteins
Peroxisome-Targeting Signal 1 Receptor
Receptors, Cytoplasmic and Nuclear
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Mitochondrion
Quality-control
Models, Biological
03 medical and health sciences
0302 clinical medicine
Peroxisomal RADAR
Organelle
Peroxisomes
Humans
Receptor
Molecular Biology
Peroxisomal targeting signal
ComputingMilieux_MISCELLANEOUS
Peroxisomal Targeting Signal 2 Receptor
Plant Proteins
030304 developmental biology
0303 health sciences
Viral matrix protein
Peroxisomal matrix
Intracellular Membranes
Cell Biology
Peroxisome
Peroxisomal matrix protein import
Transport protein
Cell biology
Protein Transport
Extended shuttle
Import of folded and oligomeric protein
Shuttling receptor
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01674889
- Volume :
- 1763
- Database :
- OpenAIRE
- Journal :
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Accession number :
- edsair.doi.dedup.....1a9dca44be08535fd2df218dd88f5116