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Safety for Patients With Celiac Disease of Baked Goods Made of Wheat Flour Hydrolyzed During Food Processing
- Publication Year :
- 2011
-
Abstract
- Background & Aims: Celiac disease (CD) is characterized by an inflammatory response to wheat gluten, rye, and barley proteins. Fermentation of wheat flour with sourdough lactobacilli and fungal proteases decreases the concentration of gluten. We evaluated the safety of daily administration of baked goods made from this hydrolyzed form of wheat flour to patients with CD. Methods: Patients were randomly assigned to consumption of 200 g per day of natural flour baked goods (NFBG) (80,127 ppm gluten; n = 6), extensively hydrolyzed flour baked goods (S1BG) (2480 ppm residual gluten; n = 2), or fully hydrolyzed baked goods (S2BG) (8 ppm residual gluten; n = 5) for 60 days. Results: Two of the 6 patients who consumed NFBG discontinued the challenge because of symptoms; all had increased levels of anti-tissue transglutaminase (tTG) antibodies and small bowel deterioration. The 2 patients who ate the S1BG goods had no clinical complaints but developed subtotal atrophy. The 5 patients who ate the S2BG had no clinical complaints; their levels of anti-tTG antibodies did not increase, and their Marsh grades of small intestinal mucosa did not change. Conclusions: A 60-day diet of baked goods made from hydrolyzed wheat flour, manufactured with sourdough lactobacilli and fungal proteases, was not toxic to patients with CD. A combined analysis of serologic, morphometric, and immunohistochemical parameters is the most accurate method to assess new therapies for this disorder.
- Subjects :
- Glutens
Adolescent
Tissue transglutaminase
Food Handling
Inflammatory response
Antibodie
Flour
Wheat flour
Wheat gluten
Enzyme-Linked Immunosorbent Assay
Baked goods
Antibodies
Hydrolysis
Young Adult
Gluten Challenge
Humans
Medicine
Food science
Child
Triticum
chemistry.chemical_classification
Lactobacillu
biology
Hepatology
business.industry
Fungi
Gastroenterology
food and beverages
Gluten
Hydrolysi
Immunohistochemistry
Immunoglobulin A
Lactobacillus
Celiac Disease
Peptide Hydrolase
chemistry
Sourdough
Wheat Flour
Food processing
biology.protein
Food Technology
business
Peptide Hydrolases
Diet Therapy
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....1a9b2204da4832c4e3a5ec05fb7e2ba4