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Clinical and electrocardiographic variables associated with increased risk of ventricular septal defect in acute anterior myocardial infarction

Clinical and electrocardiographic variables associated with increased risk of ventricular septal defect in acute anterior myocardial infarction

Authors :
Kathy B. Gates
Robert J. Siegel
Gabriel I. Barbash
Yochai Birnbaum
Brian S. Crenshaw
Galen S. Wagner
Robert M. Califf
Christopher B. Granger
Michael C. Fishbein
Trevor D. Thompson
Source :
The American journal of cardiology. 86(8)
Publication Year :
2000

Abstract

It is unknown whether the risk factors associated with the development of ventricular septal defect (VSD) after acute myocardial infarction (MI) remain the same when thrombolytic therapy is used, nor have specific electrocardiographic patterns of acute MI associated with the development of VSD been identified. Our study population included patients with an anterior MI enrolled in the GUSTO-I study. Baseline clinical data were collected prospectively for all patients. Patients in whom VSD was suspected by the local investigators at each site were evaluated retrospectively. Baseline clinical and electrocardiographic variables were compared between 2 groups: 10,847 patients without VSD (99.6%) and 48 patients with confirmed VSD (0.4%). Multivariate analysis showed the following clinical variables to be independent predictors of VSD: age (odds ratio [OR] 2.19, 95% confidence intervals [CI] 1.62 to 2.98; p

Details

ISSN :
00029149
Volume :
86
Issue :
8
Database :
OpenAIRE
Journal :
The American journal of cardiology
Accession number :
edsair.doi.dedup.....1a968737ab007efaa35c687612c4c42d