Back to Search
Start Over
Sarin intoxication elevates plasma pralidoxime
- Source :
- Toxicology Letters. 28:17-21
- Publication Year :
- 1985
- Publisher :
- Elsevier BV, 1985.
-
Abstract
- Groups of guinea pigs were injected with a range of dosages for sarin (0, 140, 279, 557 micrograms/kg) followed by pralidoxime (2-PAM) and atropine sulfate (16 mg/kg). Poisoning by sarin in these animals elevated plasma pralidoxime content in a dose-dependent manner within 10 min of intoxication. Plasma levels after administration of 3.12 mg/kg of 2-PAM were elevated from a control mean of 6.18 micrograms/ml to a maximum of 13.78 micrograms/ml in animals given 557 micrograms/kg of sarin at 2 min after the injection of the therapeutic compounds. This suggests that pathophysiological changes following intoxication by potent inhibitors of cholinesterase result in a decrease in the rate and extent of distribution of therapeutic compounds. This effect is most likely a consequence of changes in cardiovascular functions influencing blood flow to various organs.
- Subjects :
- Sarin
Pralidoxime Compounds
Pralidoxime
biology
Dose
Guinea Pigs
General Medicine
Pharmacology
Toxicology
Cardiovascular functions
Pathophysiology
chemistry.chemical_compound
Organophosphate Poisoning
chemistry
Regional Blood Flow
biology.protein
Atropine sulfate
medicine
Animals
Distribution (pharmacology)
Cholinesterase
medicine.drug
Subjects
Details
- ISSN :
- 03784274
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Toxicology Letters
- Accession number :
- edsair.doi.dedup.....1a914bbdc94f3f7df4fa457355f30508