Supplementary Data from Towards Multidrug Adaptive Therapy

Figure S1, Tables S1, S2. Table S1: Competition parameters for Lupron and Abiraterone treatment; Table S2: Competition parameters for no treatment; Figure S1: After-action analysis of patient-specific subpopulations Normalized subpopulations over time (equation 4) for testosterone-dependent (T+, yellow), testosterone-producing (TP, blue), and testosterone-independent cells (T-, green). Timing of treatment received under clinical protocol is indicated (top) for Lupron & Abiraterone (red) and Lupron only (blue). Parameterization of the model is performed by least-squares fit to PSA data from clinical trial NCT02415621 (see figure 3).