Back to Search
Start Over
Role of Active Oxygen Species in the Toxic Effects of Glucosone on Mammalian Cells
- Source :
- Journal of Nutritional Science and Vitaminology. 38:593-601
- Publication Year :
- 1992
- Publisher :
- Center for Academic Publications Japan, 1992.
-
Abstract
- Glucosone (D-arabino-hexos-2-ulose), a typical enediol product formed both in the Maillard reaction and gamma-radiolysis of sugars, decreased survival of Chinese hamster lung V79 cells, which were incubated under MEM for 4 h. Inhibition of the decrease in cell survival by catalase and SOD suggests the role of active oxygen species, namely H2O2 and O2-, in the biological effects of glucosone. H2O2 was formed in the medium during oxidative degradation of glucosone. Inhibition of the formation of H2O2 by SOD indicates that the formation of H2O2 and the consequent decrease of the cell survival was enhanced by O2-. These results suggest that the mechanisms of the effects of glucosone on the mammalian cells in the absence of Cu2+ are different from those in the presence of Cu2+.
- Subjects :
- inorganic chemicals
Cell Survival
Medicine (miscellaneous)
Chinese hamster
Cell Line
symbols.namesake
chemistry.chemical_compound
Cricetulus
Glycation
Cricetinae
Ketoses
Animals
Hydrogen peroxide
Cytotoxicity
Lung
Nutrition and Dietetics
biology
Superoxide Dismutase
Chemistry
Hydrogen Peroxide
V79 cells
Catalase
biology.organism_classification
Active oxygen
Maillard reaction
Biochemistry
symbols
biology.protein
Reactive Oxygen Species
Subjects
Details
- ISSN :
- 18817742 and 03014800
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Nutritional Science and Vitaminology
- Accession number :
- edsair.doi.dedup.....1a8bb000e772b4b49351d77424c2cab4