Back to Search
Start Over
Fatigue reduction diet in breast cancer survivors: a pilot randomized clinical trial
- Source :
- Breast Cancer Research and Treatment. 161:299-310
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Fatigue is a prevalent and burdensome effect of breast cancer. Fatigue has been linked to chronic inflammation, and diets high in antioxidant nutrients have been associated with lesser prevalence and severity of fatigue. Studies are needed, however, to test if antioxidant-rich diets could improve fatigue.Pilot, randomized, trial conducted between January 2014 and April 2015, to investigate if a 3-month diet rich in fruit, vegetables, whole grains, and omega-3 fatty acid-rich foods, named the fatigue reduction diet (FRD), improved fatigue and sleep compared to an attention control, named the general health curriculum (GHC). 30 stage 0 to III breast cancer survivors, who had completed cancer treatments, were randomized: 15 receiving the FRD and 15 the GHC. Primary outcome was change in fatigue, as measured by the brief fatigue Inventory, from baseline to 3 months analyzed using linear mixed models. Secondary analyses were changes in sleep quality, serum carotenoids, and fatty acids.From baseline to 3-month fatigue improved by 44 ± 39% in FRD compared to 8 ± 34% in GHC (p = 0.01); sleep quality improved by 2.5 ± 3.3 points in FRD, and diminished by 0.9 ± 2.3 in GHC (p = 0.03); serum total carotenoids (p 0.01), β-cryptoxanthin (p = 0.02), lutein (p = 0.05), zeaxanthin (p = 0.01), lycopene (p = 0.05), omega-3 fatty acids (p 0.01), and ratio of omega-3:omega-6 fatty acids (p = 0.02) were significantly increased, and percent saturated fatty acids were decreased (p = 0.04) in FRD; γ-tocopherol was significantly increased in GHC (p = 0.03), and there was a significant visit by group difference for α-carotene between the study groups (p = 0.05).The FRD intervention improved fatigue and sleep in breast cancer survivors compared to the GHC. FRD diet could provide a non-toxic treatment strategy for persistent fatigue.
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_specialty
Breast Neoplasms
Pilot Projects
Article
Antioxidants
Whole grains
Body Mass Index
law.invention
03 medical and health sciences
0302 clinical medicine
Breast cancer
Randomized controlled trial
Risk Factors
law
Internal medicine
Fatty Acids, Omega-3
Vegetables
Humans
Medicine
Survivors
Cancer-related fatigue
Fatigue
Aged
Neoplasm Staging
Sleep quality
business.industry
Middle Aged
medicine.disease
Combined Modality Therapy
Diet
Treatment Outcome
030104 developmental biology
Oncology
Fruit
030220 oncology & carcinogenesis
Physical therapy
Female
medicine.symptom
Energy Intake
business
Biomarkers
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 161
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....1a8635c70132906ed5df236ff7342461