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Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence
- Source :
- Retrovirology, Vol 16, Iss 1, Pp 1-14 (2019), Retrovirology
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo’s group, is the etiologic agent of both cancer and inflammatory diseases. Despite approximately 40 years of investigation, the prognosis for afflicted patients remains poor with no effective treatments. The virus persists in the infected host by evading the host immune response and inducing proliferation of infected CD4+T-cells. Here, we will review the role that viralorf-Iprotein products play in altering intracellular signaling, protein expression and cell–cell communication in order to escape immune recognition and promote T-cell proliferation. We will also review studies oforf-Imutations found in infected patients and their potential impact on viral load, transmission and persistence. Finally, we will compare theorf-Igene in HTLV-1 subtypes as well as related STLV-1.
- Subjects :
- CD4-Positive T-Lymphocytes
lcsh:Immunologic diseases. Allergy
rex-orf-I
viruses
T-cell leukemia
orf-I
Review
ATLL
Virus
p12/p8
03 medical and health sciences
Immune system
Virology
MHC class I
Humans
Viral Regulatory and Accessory Proteins
030304 developmental biology
Cell Proliferation
0303 health sciences
Human T-lymphotropic virus 1
HTLV-1 associated myelopathy/tropical spastic paraparesis
biology
030306 microbiology
Transmission (medicine)
Immune evasion
STLV-1
Viral Load
biology.organism_classification
HTLV-I Infections
Paraparesis, Tropical Spastic
3. Good health
Infectious Diseases
HTLV-1
Adult T-cell leukemia/lymphoma
biology.protein
Antibody
HAM/TSP
Simian T-lymphotropic virus 1
lcsh:RC581-607
Viral load
Subjects
Details
- Language :
- English
- ISSN :
- 17424690
- Volume :
- 16
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Retrovirology
- Accession number :
- edsair.doi.dedup.....1a82f01b206171644a8458054a6a40b5