3D-Printed masks as a new approach for immobilization in radiotherapy - a study of positioning accuracy

// Matthias Felix Haefner 1, 2, * , Frederik Lars Giesel 3, * , Matthias Mattke 1, 2 , Daniel Rath 3 , Moritz Wade 3, 4 , Jacob Kuypers 3, 4 , Alan Preuss 3, 4 , Hans-Ulrich Kauczor 5 , Jens-Peter Schenk 5 , Juergen Debus 1, 2 , Florian Sterzing 2, 6 and Roland Unterhinninghofen 4, 7 1 Department of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, Germany 2 National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), 69120 Heidelberg, Germany 3 Department of Nuclear Medicine, Heidelberg University Hospital, 69120 Heidelberg, Germany 4 Institute of Antropomatics and Robotics, Karlsruhe Institute of Technology (KIT), 76131 Karlsruhe, Germany 5 Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany 6 Department of Radiation Oncology Kempten, 87439 Kempten, Germany 7 Institute of Robotics and Mechatronics, German Aerospace Center, 82234 Oberpfaffenhofen-Wesling, Germany * These authors contributed equally to the manuscript and share the first authorship Correspondence to: Matthias Felix Haefner, email: matthias.haefner@med.uni-heidelberg.de Keywords: immobilization; radiotherapy; 3D-printing; setup accuracy; head mask Received: October 07, 2017 Accepted: January 02, 2018 Published: January 08, 2018 ABSTRACT We developed a new approach to produce individual immobilization devices for the head based on MRI data and 3D printing technologies. The purpose of this study was to determine positioning accuracy with healthy volunteers. 3D MRI data of the head were acquired for 8 volunteers. In-house developed software processed the image data to generate a surface mesh model of the immobilization mask. After adding an interface for the couch, the fixation setup was materialized using a 3D printer with acrylonitrile butadiene styrene (ABS). Repeated MRI datasets (n=10) were acquired for all volunteers wearing their masks thus simulating a setup for multiple fractions. Using automatic image-to-image registration, displacements of the head were calculated relative to the first dataset (6 degrees of freedom). The production process has been described in detail. The absolute lateral (x), vertical (y) and longitudinal (z) translations ranged between −0.7 and 0.5 mm, −1.8 and 1.4 mm, and −1.6 and 2.4 mm, respectively. The absolute rotations for pitch (x), yaw (y) and roll (z) ranged between −0.9 and 0.8°, −0.5 and 1.1°, and −0.6 and 0.8°, respectively. The mean 3D displacement was 0.9 mm with a standard deviation (SD) of the systematic and random error of 0.2 mm and 0.5 mm, respectively. In conclusion, an almost entirely automated production process of 3D printed immobilization masks for the head derived from MRI data was established. A high level of setup accuracy was demonstrated in a volunteer cohort. Future research will have to focus on workflow optimization and clinical evaluation.