Back to Search
Start Over
Rationale, Design, and Implementation of Intensive Risk Factor Treatment in the CREST2 Trial
- Source :
- Stroke
- Publication Year :
- 2020
-
Abstract
- Background and Purpose: The CREST2 trial (Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis) is comparing intensive medical management (IMM) alone to IMM plus revascularization with carotid endarterectomy or transfemoral carotid artery stenting for preventing stroke or death within 44 days after randomization or ipsilateral ischemic stroke thereafter. There are extensive clinical trial data on outcomes after revascularization of asymptomatic carotid stenosis, but not for IMM. As such, the experimental treatment in CREST2 is IMM, which is described in this article. Methods: IMM consists of aspirin 325 mg/day and intensive risk factor management, primarily targeting systolic blood pressure Results: The mean baseline LDL of 80.5 mg/dL improved to 66.7 mg/dL. The mean baseline systolic blood pressure of 139.7 mm Hg improved to 130.3 mm Hg. The proportion of patients in-target improved from 43% to 61% for systolic blood pressure P Conclusions: The rigorous multimodal approach to intensive stroke risk factor management in CREST2 has resulted in significant improvements in risk factor control that will enable a comparison of cutting-edge medical care to revascularization in patients with asymptomatic carotid stenosis. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02089217.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Blood Pressure
Asymptomatic
Article
Risk Factors
Internal medicine
medicine
Humans
Carotid Stenosis
Risk factor
Life Style
Aged
Advanced and Specialized Nursing
Carotid revascularization
business.industry
Smoking
Stent
Disease Management
Middle Aged
medicine.disease
Stroke
Stenosis
Blood pressure
Treatment Outcome
Research Design
Hypertension
Cardiology
Female
Neurology (clinical)
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Stroke
- Accession number :
- edsair.doi.dedup.....1a5c0b68bf82fdcbc94275a2fac4c819