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Two-year performance of a Nestorone®-releasing contraceptive implant: a three-center study of 300 women
- Source :
- Contraception. 69:137-144
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- A 2-year trial of a single Nestorone® (NES) rod implant was conducted at three Latin American centers, each enrolling 100 women. We studied the safety, effectiveness and acceptability of this progestin-releasing contraceptive implant. Three pregnancies occurred, the last at 18 months of use. Because no pregnancies were expected in the first 18 months, the trial was halted. At that time, 224 women had completed at least 18 months of use, and 99 women had used the implant for more than 24 months. Few participants used adjunctive contraception between the time the study was halted and the time they had their implant removed. No additional pregnancies occurred before the removal of the last implant. The 2-year cumulative pregnancy rate was 1.7 per 100 with a Pearl index of 0.6 per 100 for the 2-year period. The 1-year and 2-year continuation rates were 80.5 and 66.7 per 100, respectively. Menstrual and medical disturbances were the principal reasons for discontinuation, followed by planned pregnancy. Headache and weight gain frequently led to discontinuation. The NES implant had little important effect on most clinical chemistry and lipid parameters. Over the study course, the mean change in hemoglobin was
- Subjects :
- Adult
medicine.medical_specialty
Patient Dropouts
Adolescent
Population
03 medical and health sciences
0302 clinical medicine
Pregnancy
Contraceptive Agents, Female
medicine
Humans
030212 general & internal medicine
education
Menstruation Disturbances
Drug Implants
Analysis of Variance
education.field_of_study
Chi-Square Distribution
030219 obstetrics & reproductive medicine
Obstetrics
business.industry
Obstetrics and Gynecology
Pregnancy, Unwanted
3. Good health
Surgery
Discontinuation
Clinical trial
Pregnancy rate
Treatment Outcome
Reproductive Medicine
Family planning
Female
Implant
Contraceptive implant
business
Pearl Index
Brazil
Norprogesterones
Follow-Up Studies
Subjects
Details
- ISSN :
- 00107824
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Contraception
- Accession number :
- edsair.doi.dedup.....1a44f51be5c6f672cb98147ff65e1a9c