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Subclinical renal tubular acidosis in patients with primary and secondary Sjögren's syndrome: a possible marker of disease progression
- Source :
- Modern Rheumatology. 12:318-322
- Publication Year :
- 2002
- Publisher :
- Oxford University Press (OUP), 2002.
-
Abstract
- To clarify the prevalence of subclinical renal tubular acidosis (RTA) and its association with clinical and laboratory parameters in primary and secondary Sjögren's syndrome (SS), an acid-loading test was conducted. Subclinical RTA was found in 32% of patients with SS. The prevalence of subclinical RTA in primary and secondary SS was about the same (31.6% and 33.3%, respectively). Significant longer duration of illness, more severely decreased salivary excretion, decreased lymphocyte number, higher serum levels of IgG and IgA, and higher frequency of anti-SS-A (Ro) and SS-B (La) antibodies were found in patients with subclinical RTA. These results suggested that subclinical RTA may be a characteristic manifestation both in primary and secondary SS, along with the progression of immunologic dysfunction, when the illness seemed to be indolent.
- Subjects :
- medicine.medical_specialty
Pathology
biology
business.industry
viruses
Lymphocyte
Disease progression
biochemical phenomena, metabolism, and nutrition
medicine.disease
Gastroenterology
Rheumatology
Renal tubular acidosis
medicine.anatomical_structure
Internal medicine
medicine
biology.protein
Secondary Sjögren's syndrome
In patient
Antibody
business
Subclinical infection
Subjects
Details
- ISSN :
- 14397609 and 14397595
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Modern Rheumatology
- Accession number :
- edsair.doi.dedup.....1a3e95b6359dd2d6756eea867ef6f83c