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Identification of cells migrating from the thecal layer of ovarian follicles
- Source :
- Cell and Tissue Research. 353:189-194
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- In the mammalian ovary, oocytes are contained within ovarian follicles. These consist in an oocyte surrounded by supporting cells: an inner layer of granulosa cells and an outer layer of thecal cells separated by a basal lamina. At any one time, a developing cohort of follicles exists, from which only a small species-specific number are selected for continued development towards ovulation, with the remainder dying by follicular atresia. Here, we use in vitro methods to study interactions between two follicles in culture (follicle co-cultures). We show that, when two individual follicles are grown together in culture, cells and cellular processes migrate from the outer thecal layer of one follicle to the thecal layer of the other co-cultured follicle. These cells are identified as a mixed population containing primarily endothelial but also neuronal cells. Both are able to migrate through the ovarian interstitum, making contact with the basal lamina of other follicles and with similar cells from these other follicles. Networks of such cells might be involved in interfollicular communication and in the coordination of follicle selection for ovulation.
- Subjects :
- endocrine system
medicine.medical_specialty
Histology
media_common.quotation_subject
Green Fluorescent Proteins
Population
Cell Communication
Biology
Pathology and Forensic Medicine
Mice
Follicle
Organ Culture Techniques
Cell Movement
Internal medicine
Follicular phase
medicine
Animals
education
Ovulation
Cells, Cultured
media_common
education.field_of_study
Granulosa Cells
Follicular atresia
Endothelial Cells
Cell Biology
Cell biology
Mice, Inbred C57BL
Endocrinology
medicine.anatomical_structure
Theca
Theca Cells
Oocytes
Female
Basal lamina
Folliculogenesis
Subjects
Details
- ISSN :
- 14320878 and 0302766X
- Volume :
- 353
- Database :
- OpenAIRE
- Journal :
- Cell and Tissue Research
- Accession number :
- edsair.doi.dedup.....1a2ee80cb6e27e9143401a7d3c6fff9b