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Effects of Anesthesia and Surgery on Plasma Endothelin Levels

Effects of Anesthesia and Surgery on Plasma Endothelin Levels

Authors :
Kazuwa Nakao
Toyohiko O'higashi
Yoshihiko Saito
Kenjiro Mori
Tatsuo Magaribuchi
Gotaro Shirakami
Koh Shingu
Source :
Survey of Anesthesiology. 39:358
Publication Year :
1995
Publisher :
Ovid Technologies (Wolters Kluwer Health), 1995.

Abstract

To investigate the clinical significance of endothelin (ET), a potent and long-acting vasoconstrictor peptide in anesthesia and surgery, we measured plasma ET-like immunoreactivity (ET-LI) levels by using radioimmunoassay in patients undergoing various kinds of surgery under general anesthesia. No significant changes in plasma ET-LI levels were observed in patients undergoing relatively minor surgery under general anesthesia with nitrous oxide and halothane (n=6), enflurane (n=6), or isoflurane (n=5). Although plasma ET-LI levels after surgery in patients undergoing total knee replacement (12.4±0.9 [mean±SEM] pg/mL, n=7), hysterectomy (11.4±0.6 pg/mL, n=8) or cholecystectomy (14.8±1.2 pg/mL, n=9) were no different from those before surgery, plasma ET-LI levels after surgery in patients undergoing gastrectomy (20.4±1.9 pg/mL, n=15), esophagectomy (24.7±2.5 pg/mL, n=12), hepatectomy (27.5±3.4 pg/mL, n=12), or heart surgery (43.1±4.1 pg/mL, n=18) were higher than those before surgery (P

Details

ISSN :
00396206
Volume :
39
Database :
OpenAIRE
Journal :
Survey of Anesthesiology
Accession number :
edsair.doi.dedup.....1a1b9ff1e0e260078409135ee9fd0b1d
Full Text :
https://doi.org/10.1097/00132586-199512000-00020