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Effects of Anesthesia and Surgery on Plasma Endothelin Levels
Effects of Anesthesia and Surgery on Plasma Endothelin Levels
- Source :
- Survey of Anesthesiology. 39:358
- Publication Year :
- 1995
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1995.
-
Abstract
- To investigate the clinical significance of endothelin (ET), a potent and long-acting vasoconstrictor peptide in anesthesia and surgery, we measured plasma ET-like immunoreactivity (ET-LI) levels by using radioimmunoassay in patients undergoing various kinds of surgery under general anesthesia. No significant changes in plasma ET-LI levels were observed in patients undergoing relatively minor surgery under general anesthesia with nitrous oxide and halothane (n=6), enflurane (n=6), or isoflurane (n=5). Although plasma ET-LI levels after surgery in patients undergoing total knee replacement (12.4±0.9 [mean±SEM] pg/mL, n=7), hysterectomy (11.4±0.6 pg/mL, n=8) or cholecystectomy (14.8±1.2 pg/mL, n=9) were no different from those before surgery, plasma ET-LI levels after surgery in patients undergoing gastrectomy (20.4±1.9 pg/mL, n=15), esophagectomy (24.7±2.5 pg/mL, n=12), hepatectomy (27.5±3.4 pg/mL, n=12), or heart surgery (43.1±4.1 pg/mL, n=18) were higher than those before surgery (P
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Nitrous Oxide
Radioimmunoassay
Anesthesia, General
Enflurane
medicine
Humans
Aged
Hysterectomy
Isoflurane
business.industry
Endothelins
Middle Aged
Surgery
Anesthesiology and Pain Medicine
Esophagectomy
Anesthesia
Surgical Procedures, Operative
Gastrectomy
Female
Hepatectomy
Halothane
Endothelin receptor
business
medicine.drug
Subjects
Details
- ISSN :
- 00396206
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Survey of Anesthesiology
- Accession number :
- edsair.doi.dedup.....1a1b9ff1e0e260078409135ee9fd0b1d
- Full Text :
- https://doi.org/10.1097/00132586-199512000-00020