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MICRORNA PROFILES OF IN VITRO CELLULAR SENESCENCE OF HUMAN OSTEOBLASTS

Authors :
Po-Lin Kuo
Hsu Yl
Wang K
Ming Shyan Huang
Publication Year :
2017
Publisher :
Oxford University Press, 2017.

Abstract

Introduction: Osteoporosis is characterized by loss of bone tissue while age is considered as the common risk factor. There is an impaired osteoblastic bone formation in comparison with osteoclastic bone resorption during aging. One of the possible cellular mechanisms of age-related bone loss is osteoblast senescence. MicroRNAs (miRNAs) regulate the expression of mRNA/protein targets and play an important part in cellular senescence. The purpose of this study was to investigate alternations in the miRNAs that are expressed in replicative senescence of human osteoblast cells.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....1a1723a1aff71dceb0e2d50346c6e96c