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Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study

Authors :
Md. Mizanur Rahaman
Mohammad Torequl Islam
Radu Bagiu
Javad Sharifi-Rad
Jorge Sastre-Serra
Monica Butnariu
Miquel Martorell
Shabnam Sharmin
Iulia Cristina Bagiu
Source :
Cancer Cell International, Vol 21, Iss 1, Pp 1-19 (2021), Cancer Cell International
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional therapies, this death rate is on the verge of growth. New effective therapeutic compounds and treatment method is the best way to look out for in this critical time. For instance, new synthetic derivatives/ analogues synthesized from different compounds can be a ray of hope. Numerous synthetic compounds have been seen enhancing the apoptosis and autophagic pathway that directly exerts cytotoxicity towards different breast cancer cell lines. To cease the ever-growing resistance of multi-drug resistant cells against anti-breast cancer drugs (Doxorubicin, verapamil, tamoxifen) synthetic compounds may play a vital role by increasing effectivity, showing synergistic action. Many recent and previous studies have reported that synthetic derivatives hold potentials as an effective anti-breast cancer agent as they show great cytotoxicity towards cancer cells, thus can be used even vastly in the future in the field of breast cancer treatment. This review aims to identify the anti-breast cancer properties of several synthetic derivatives against different breast cancer and multi-drug-resistant breast cancer cell lines with their reported mechanism of action and effectivity.

Details

ISSN :
14752867
Volume :
21
Database :
OpenAIRE
Journal :
Cancer Cell International
Accession number :
edsair.doi.dedup.....1a03e1ac39885fb42d8a1ff6b9f44184
Full Text :
https://doi.org/10.1186/s12935-021-02309-9