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Synthesis of [3 H] and [14 C]genipin
- Source :
- Journal of Labelled Compounds and Radiopharmaceuticals. 63:196-202
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- [3 H]Genipin was synthesized in a single step by Ir(I) catalyzed hydrogen isotope exchange. Conditions for selective exchange of the sp2 CH bond ortho to the methyl ester functionality were developed through deuterium modeling studies through a catalyst screen. Optimized conditions so obtained were then utilized with tritium gas to generate [3 H]genipin at a specific activity of 18.5 Ci/mmol. Racemic [14 C]genipin was prepared in eight steps in overall 5.4% radiochemical yield from potassium [14 C]cyanide.
- Subjects :
- inorganic chemicals
Potassium
Cyanide
chemistry.chemical_element
01 natural sciences
Biochemistry
030218 nuclear medicine & medical imaging
Analytical Chemistry
Catalysis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Drug Discovery
QD
Radiology, Nuclear Medicine and imaging
Spectroscopy
Tritium illumination
010405 organic chemistry
Organic Chemistry
0104 chemical sciences
Deuterium
chemistry
Yield (chemistry)
Genipin
Tritium
Nuclear chemistry
Subjects
Details
- ISSN :
- 03624803
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Journal of Labelled Compounds and Radiopharmaceuticals
- Accession number :
- edsair.doi.dedup.....1a0283f6e7cf473fa399212c4113fd94