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MODELS FOR ASSESSING SCAR TISSUE INHIBITORS
- Source :
- Retina. 5:239-252
- Publication Year :
- 1985
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1985.
-
Abstract
- The main purpose of animal models for proliferative vitreoretinopathy (PVR) is to develop pharmacologic therapies for this common cause of blindness. A very large number of pharmacologic agents appear to have potential use in this application by preventing cell proliferation and/or contraction. In practice, however, it has been found that prohibitively extensive numbers of animals and laboratory services are required to establish drug efficacy, safety, and dosage regimes. To lessen this work load and to accelerate drug screening programs, the authors have developed an in vitro model for PVR based on chorioretinal fibroblast growth in three-dimensional collagen lattices. This model yields precise data on the effect of drugs on cell proliferation and contractility. Trifluoperazine, colchicine, 5-fluorouracil, dexamethasone, and penicillamine were screened in this model. The first three agents were found to be inhibitory; on the basis of the pharmaco kinetic data, obtained dosage regimes for animal testing were developed. The results obtained are discussed in terms of the in vitro model and the biochemical action of these drugs on the cellular events in PVR. In vitro screening of drugs prior to animal testing offers a significant advance in the quest for a pharmacologic prevention of blindness due to PVR.
- Subjects :
- DNA Replication
Drug
Proliferative vitreoretinopathy
Eye Diseases
media_common.quotation_subject
Pharmacology
Blindness
Dexamethasone
Efficacy
Contractility
Cicatrix
chemistry.chemical_compound
Retinal Diseases
Animals
Medicine
Colchicine
Animal testing
media_common
business.industry
Penicillamine
Retinal Detachment
DNA
General Medicine
Fibroblasts
medicine.disease
Trifluoperazine
Vitreous Body
Disease Models, Animal
Ophthalmology
chemistry
Collagen
Fluorouracil
Rabbits
business
Cell Division
medicine.drug
Subjects
Details
- ISSN :
- 0275004X
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Retina
- Accession number :
- edsair.doi.dedup.....19fbfb742015516f276360aa9ea2d5af